Search results for "Raman microspectroscopy"

showing 2 items of 2 documents

Combining Pharmacokinetics and Vibrational Spectroscopy: MCR-ALS Hard-and-Soft Modelling of Drug Uptake In Vitro Using Tailored Kinetic Constraints

2022

Raman microspectroscopy is a label-free technique which is very suited for the investigation of pharmacokinetics of cellular uptake, mechanisms of interaction, and efficacies of drugs in vitro. However, the complexity of the spectra makes the identification of spectral patterns associated with the drug and subsequent cellular responses difficult. Indeed, multivariate methods that relate spectral features to the inoculation time do not normally take into account the kinetics involved, and important theoretical information which could assist in the elucidation of the relevant spectral signatures is excluded. Here, we propose the integration of kinetic equations in the modelling of drug uptake…

Multivariate Curve Resolution-Alternating Least SquaresBiological and Chemical PhysicsSystems BiologyMultivariate Curve Resolution-Alternating Least Squares; pharmacokinetics; Raman microspectroscopy; chemometricsGeneral MedicineSpectrum Analysis RamanRaman microspectroscopyKineticsMultivariate AnalysisHumansPharmacokineticsLeast-Squares AnalysisChemometricsBiochemistry Biophysics and Structural Biology
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Temperature rise during laser-induced self-organization of nanoparticle gratings revealed by Raman microspectroscopy and electron microscopy

2016

International audience

[PHYS]Physics [physics]Materials science[ PHYS ] Physics [physics]NanoparticleNanotechnology02 engineering and technology[CHIM.MATE]Chemical Sciences/Material chemistry010402 general chemistry021001 nanoscience & nanotechnologyLaser01 natural sciences0104 chemical scienceslaw.inventionRaman microspectroscopylaw[ CHIM.MATE ] Chemical Sciences/Material chemistryElectron microscope0210 nano-technologyComputingMilieux_MISCELLANEOUS
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